Genetics and genomic medicine in Indonesia

Multivariate Analysis of Morphological Traits of Local Goats in Central Java, Indonesia

The objective of this research was to discriminate four local breeds of goat in Central Java-Indonesia using multivariate analysis. Data from eight morphological traits of four goat breeds, namely Kejobong goat (JG), Etawa Grade goat (EGG), Kacang goat (KG) and Jawarandu goat (RG) originated from Purbalingga, Purworejo, Grobogan and Pemalang regencies, respectively, were used. One hundred and s...

A Comparison of the Sensitivity of the BayesC and Genomic Best Linear Unbiased Prediction(GBLUP) Methods of Estimating Genomic Breeding Values under Different Quantitative Trait Locus(QTL) Model Assumptions

The objective of this study was to compare the accuracy of estimating and predicting breeding values using two diverse approaches, GBLUP and BayesC, using simulated data under different quantitative trait locus(QTL) effect distributions. Data were simulated with three different distributions for the QTL effect which were uniform, normal and gamma (1.66, 0.4). The number of QTL was assumed to be...

A Novel Splice Site Mutation in HPS1 Gene is Associated with Hermansky-Pudlak Syndrome-1 (HPS1) in an Iranian Family

Multiple Inherited Thrombophilic Gene Polymorphisms in Spontaneous Abortions in Turkish Population

The aim of this study was to investigate the possible role of multiple inherited thrombophilic gene variations in women with unexplained spontaneous abortions. For this purpose, the Factor V Leiden (FVL) (rs6025), Prothrombin G20210A (rs1799963), MTHFR C677T (rs1801133), PAI-1 4G/5G (rs1799889), ACE I/D (rs1799752), eNOS E298D (rs1799983), and Apo E E2/E3/E4 (rs429358) polymorphisms were genoty...

Achieving Effective Treatment Goals against New Coronavirus (SARS-CoV-2) by Identifying the Molecular Details of the Virus Genome

Introduction: We are currently faced with a global epidemic of a new coronavirus (SARS-CoV-2) that It affects not only thousands of people in China, but all over the world. The rapid increase in cases appears to be related to the active genome of the virus, which may affect its pathogenesis. An understanding of the novel coronavirus genomic organization will help us in understanding their origi...